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Formulation and Development of Modified Release Biphasic Compressed Tablet of Propranolol Hydrochloride

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Formulation and Development of Modified Release Biphasic Compressed Tablet of Propranolol Hydrochloride


Mrs. Poonam Jaykar Patil | Dr. Durgacharan A. Bhagwat | Ms. Rutuja Rajendra Shah | Dr. Jhon I. D’souza



Mrs. Poonam Jaykar Patil | Dr. Durgacharan A. Bhagwat | Ms. Rutuja Rajendra Shah | Dr. Jhon I. D’souza "Formulation and Development of Modified Release Biphasic Compressed Tablet of Propranolol Hydrochloride" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-1, December 2020, pp.1375-1383, URL: https://www.ijtsrd.com/papers/ijtsrd38190.pdf

Quick/slow drug delivery system involves the use of compressed core, consisting of sustained release tablet, which is coated by compression over the whole surface with fast dispersible formulation. Propranolol hydrochloride, a non-selective beta-adrenergic blocker has widely used in the treatment of hypertension and angina pectoris with frequent administration. Aim of present study was to develop press-coated tablet system to achieve quick/slow release of the drug are the main purposes of biphasic drug delivery system to avoid frequent administration with increasing patient compliance and therapeutic efficacy. In this study immediate layer which was prepared using croscarmellose sodium, crospovidone and sodium starch glycol ate which was compressed on core tablet prepared by using HPMC and Ethyl cellulose. Results showed that the immediate layer dissolved within four minutes and core tablet releases drug for 12 hrs in controlled manner with zero order release kinetics.

Biphasic release; multiple unit dosage form; compressed tablets; Tablet characteristic, Tablet dissolution


IJTSRD38190
Volume-5 | Issue-1, December 2020
1375-1383
IJTSRD | www.ijtsrd.com | E-ISSN 2456-6470
Copyright © 2019 by author(s) and International Journal of Trend in Scientific Research and Development Journal. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (http://creativecommons.org/licenses/by/4.0)

International Journal of Trend in Scientific Research and Development - IJTSRD having online ISSN 2456-6470. IJTSRD is a leading Open Access, Peer-Reviewed International Journal which provides rapid publication of your research articles and aims to promote the theory and practice along with knowledge sharing between researchers, developers, engineers, students, and practitioners working in and around the world in many areas like Sciences, Technology, Innovation, Engineering, Agriculture, Management and many more and it is recommended by all Universities, review articles and short communications in all subjects. IJTSRD running an International Journal who are proving quality publication of peer reviewed and refereed international journals from diverse fields that emphasizes new research, development and their applications. IJTSRD provides an online access to exchange your research work, technical notes & surveying results among professionals throughout the world in e-journals. IJTSRD is a fastest growing and dynamic professional organization. The aim of this organization is to provide access not only to world class research resources, but through its professionals aim to bring in a significant transformation in the real of open access journals and online publishing.

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